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Bagaev et al. identify four tumor microenvironment (TME) subtypes that are conserved across diverse cancers and correlate with immunotherapy response in melanoma, bladder, and …
The subtypes of tumor immune microenvironment (TIME) of solid tumors: Inflamed, immune-excluded, and immune-desert, based on the levels of cytotoxic T lymphocytes infiltration at …
The tumor microenvironment (TME) is an heterogenous milieu composed not only by cancer cells, but also by different cell types that can contribute to tumoral escape of immune surveillance …
Jun 1, 2024 · The heterogeneity and immune-suppressive microenvironment within IETs contribute to drug resistance against ICIs or chemotherapeutics. Therefore, exploring the …
Jan 6, 2021 · Hypoxia is a hallmark of most solid tumors and, being a multifaceted and complex condition, shapes in a unique way the tumor microenvironment, affecting gene transcription …
Oct 21, 2021 · The Oncology Biomarker Development Group at Genentech employed single cell analyses to characterize important molecular and cellular mediators that shape the tumor …
Jun 8, 2023 · Checkpoint inhibitors represent an effective treatment approach for a variety of cancers through their inhibition of immune regulatory pathways within the tumor …
May 15, 2023 · FPR2 is a sex-dependent mediator of macrophage function in pancreatic cancer and can be targeted to reprogram macrophages and stimulate antitumor immunity in females.
Jun 1, 2023 · Tumour growth, progression and response to therapy are profoundly influenced by the dynamic and complex composition of the tumour microenvironment (TME). Apart from the …
Apr 29, 2022 · Editorial on the Research Topic Mechanisms of Lymphocyte Exclusion in the Tumor Microenvironment Solid tumors which have an abundance of lymphocytes penetrating …
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